Negative regulation of mRNA processing

Across TCGA patient cohorts, RNA activity of the Negative regulation of mRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, DAXX, and STMN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mRNA processing activity versus SF3B3 in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B3 →	+0.224	+0.057	<.001	<.001	3	7
GBM	DAXX →	+0.255	+0.049	<.001	<.001	3	7
LSCC	STMN1 →	+0.695	+0.051	<.001	<.001	3	7
GBM	HNRNPU →	+0.314	+0.066	<.001	<.001	3	7
GBM	ILF2 →	+0.202	+0.045	<.001	<.001	3	7
LSCC	SART3 →	+0.278	+0.045	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050686 vs SF3B3 — LSCC

Explore this scatter interactively →