Negative regulation of mRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of mRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSTL3, PCBP4, and PMM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FSTL3 grouped by Negative regulation of mRNA processing-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FSTL3 →	+2.173	+0.127	.001	.008	3	6
BREAST	PCBP4 →	+1.332	+0.147	.001	<.001	3	5
BLOOD_Leukemia	PMM1 →	+1.130	+0.223	<.001	<.001	3	5
LUNG_NSCLC_LUSC	RNF11 →	+1.320	+0.170	.007	.006	2	6
SOFT_TISSUE	NACC2 →	+0.882	+0.155	.002	.009	3	5
BREAST	ERLIN2 →	+1.298	+0.133	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FSTL3 by Negative regulation of mRNA processing activity — OVARY

Explore this box plot interactively →