Negative regulation of mRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of mRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME6, POLB, and NUP153, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mRNA processing activity versus NME6 in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NME6 →	+0.352	+0.123	.008	.008	3	4
OVARY	POLB →	+0.628	+0.132	.007	.001	3	4
STOMACH	NUP153 →	+0.801	+0.169	.007	.002	3	4
STOMACH	AURKB →	+1.155	+0.156	.001	.009	3	4
BLOOD_Leukemia	MIER2 →	-0.609	-0.123	.006	.001	3	4
URINARY_TRACT	PIP4P1 →	+0.575	+0.130	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050686 vs NME6 — OVARY

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