Positive regulation of mRNA processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of mRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2T, AUNIP, and SCHIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA processing activity versus UBE2T in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBE2T →	+0.873	+0.258	.004	.002	3	6
PDAC	AUNIP →	+0.545	+0.235	.001	<.001	3	5
LUAD	SCHIP1 →	-0.303	-0.173	.003	.001	3	5
GBM	SGCD →	-1.066	-0.278	.001	<.001	3	5
GBM	MIR924HG →	+0.836	+0.277	.002	<.001	3	5
GBM	GINS1 →	+0.602	+0.263	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050685 vs UBE2T — GBM

Explore this scatter interactively →