Positive regulation of mRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA processing pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR10K2, KLK14, and CDC42EP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR10K2 grouped by Positive regulation of mRNA processing-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10K2 →	+0.136	+0.088	.004	.005	2	6
SKIN	KLK14 →	+0.210	+0.107	.005	.006	2	5
CNS	CDC42EP5 →	+0.130	+0.108	.008	.005	2	5
CNS	PFKP →	+0.210	+0.154	<.001	<.001	3	4
BONE	CACNA1I →	+0.233	+0.128	.001	<.001	3	4
BLOOD_Leukemia	GABRA1 →	+0.274	+0.165	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR10K2 by Positive regulation of mRNA processing activity — SKIN

Explore this box plot interactively →