Positive regulation of mRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST1, EXOSC2, and CDC7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA processing activity versus MAST1 in STOMACH (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAST1 →	+2.582	+0.276	.001	<.001	3	7
BREAST	EXOSC2 →	+0.564	+0.199	.007	.003	3	7
BLOOD_Leukemia	CDC7 →	+0.714	+0.147	.001	.001	3	6
BLOOD_Lymphoma	TMBIM1 →	-1.532	-0.118	.009	.003	3	6
LUNG_NSCLC_LUAD	VRK1 →	+0.764	+0.171	.005	.001	3	6
BREAST	EZH2 →	+0.997	+0.274	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050685 vs MAST1 — STOMACH

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