Regulation of mRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA processing pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT4, RAB21, and TAS2R7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT4 grouped by Regulation of mRNA processing-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLAAT4 →	+0.299	+0.122	.004	.006	2	8
OVARY	RAB21 →	+0.285	+0.173	.003	.008	3	7
OVARY	TAS2R7 →	+0.438	+0.208	<.001	.001	3	7
OVARY	DYNC2H1 →	+0.482	+0.248	<.001	<.001	3	7
CNS	USP40 →	+0.430	+0.176	.001	<.001	3	7
CNS	OR2H1 →	+0.407	+0.141	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT4 by Regulation of mRNA processing activity — BLOOD_Leukemia

Explore this box plot interactively →