Negative regulation of epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS7, GLUD1, and RNF151, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS7 grouped by Negative regulation of epithelial cell proliferation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS7 →	-0.376	-0.242	.002	<.001	3	5
LUNG_SCLC	GLUD1 →	-0.219	-0.186	.001	.001	3	5
LUNG_SCLC	RNF151 →	-0.291	-0.196	.008	<.001	3	5
LUNG_NSCLC_LUSC	HEXIM2 →	-0.274	-0.269	.009	.008	3	4
STOMACH	CHADL →	-0.213	-0.170	.005	.004	3	4
STOMACH	RPS19 →	-0.356	-0.218	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS7 by Negative regulation of epithelial cell proliferation activity — CNS

Explore this box plot interactively →