Positive regulation of epithelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLX, TMEM130, and RPL27P5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation activity versus HLX in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HLX →	+0.336	+0.901	.002	.002	3	3
BRCA	TMEM130 →	+1.021	+1.155	<.001	<.001	3	3
BRCA	RPL27P5 →	+0.624	+1.217	.001	<.001	3	3
BRCA	LINC02752 →	+0.417	+1.208	.001	<.001	3	3
BRCA	TGFB2 →	+2.288	+1.390	.009	.001	3	3
COAD	GOLGA8A →	+0.819	+0.828	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050679 vs HLX — COAD

Explore this scatter interactively →