Positive regulation of epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALG10B, LMF1, and ARHGAP22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALG10B grouped by Positive regulation of epithelial cell proliferation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALG10B →	+0.993	+0.231	.004	<.001	3	5
LUNG_NSCLC_LUSC	LMF1 →	+1.436	+0.224	.001	.002	3	4
LUNG_NSCLC_LUSC	ARHGAP22 →	-1.587	-0.192	.003	<.001	3	4
LIVER	PCNX4 →	-1.033	-0.220	.002	<.001	3	4
LIVER	EPB41 →	+1.510	+0.166	<.001	.006	3	4
LIVER	COL13A1 →	-3.570	-0.199	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALG10B by Positive regulation of epithelial cell proliferation activity — LARGE_INTESTINE

Explore this box plot interactively →