Homocysteine metabolic process

Across TCGA patient cohorts, RNA activity of the Homocysteine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12_S248, CTH, and DPEP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homocysteine metabolic process activity versus AKAP12_S248 in LSCC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKAP12_S248 →	+0.321	+0.030	.006	.009	3	5
UCEC	CTH →	+0.553	+0.068	.001	.001	3	4
GBM	DPEP1 →	+0.989	+0.069	<.001	<.001	3	4
GBM	FMNL3 →	+0.289	+0.045	.006	.005	3	4
GBM	MEOX2 →	+0.896	+0.058	<.001	<.001	3	4
LSCC	PDGFRB →	+0.374	+0.058	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050667 vs AKAP12_S248 — LSCC

Explore this scatter interactively →