Homocysteine metabolic process

Across TCGA patient cohorts, RNA activity of the Homocysteine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-1254P, EZH2, and LSM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homocysteine metabolic process activity versus RNU6-1254P in OV (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNU6-1254P →	-0.506	-0.203	<.001	<.001	3	4
GBM	EZH2 →	-0.571	-0.161	<.001	.003	3	4
LSCC	LSM4 →	-0.559	-0.176	<.001	.001	3	4
GBM	DDX12P →	-0.592	-0.162	<.001	.003	3	4
LSCC	HAUS8 →	-0.385	-0.148	.009	.007	3	4
BRCA	BRIP1 →	-0.608	-0.185	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050667 vs RNU6-1254P — OV

Explore this scatter interactively →