Homocysteine metabolic process

Across TCGA cell cohorts, RNA activity of the Homocysteine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK36, SLC37A3, and TP53BP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK36 grouped by Homocysteine metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	STK36 →	+1.423	+1.486	.008	.001	2	5
OVARY	SLC37A3 →	+0.985	+0.980	.002	.002	3	4
CNS	TP53BP1 →	+0.701	+0.835	<.001	<.001	3	4
BLOOD_Myeloma	UNC93B1 →	+2.476	+1.982	.008	<.001	3	4
STOMACH	ADORA2B →	-2.238	-1.389	.007	<.001	3	4
STOMACH	CEP43 →	+0.725	+0.975	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK36 by Homocysteine metabolic process activity — URINARY_TRACT

Explore this box plot interactively →