Homocysteine metabolic process

Across TCGA cell cohorts, RNA activity of the Homocysteine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZKSCAN1, RASSF6, and MSL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homocysteine metabolic process activity versus ZKSCAN1 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZKSCAN1 →	+0.862	+0.269	.004	<.001	3	6
STOMACH	RASSF6 →	+2.359	+0.221	<.001	.004	3	5
LUNG_NSCLC_LUAD	MSL1 →	+0.829	+0.320	.001	<.001	3	5
BREAST	TJP3 →	+2.609	+0.253	<.001	.004	3	5
STOMACH	FBXL22 →	+0.542	+0.256	<.001	.005	3	5
LUNG_SCLC	MPIG6B →	+0.415	+0.241	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050667 vs ZKSCAN1 — STOMACH

Explore this scatter interactively →