Dermatan sulfate proteoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Dermatan sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST12, MAP3K12, and DSE, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dermatan sulfate proteoglycan metabolic process activity versus CHST12 in LAML (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CHST12 →	+0.816	+0.066	<.001	<.001	3	27
CHOL	MAP3K12 →	+0.868	+0.053	<.001	<.001	3	26
THYM	DSE →	+1.173	+0.039	<.001	<.001	3	25
MESO	RUNX2 →	+1.138	+0.049	<.001	<.001	3	25
GBM	POM121L9P →	+0.588	+0.029	<.001	<.001	3	25
MESO	FBN1 →	+1.581	+0.036	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050655 vs CHST12 — LAML

Explore this scatter interactively →