Dermatan sulfate proteoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Dermatan sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRU, COL6A2, and PGAM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dermatan sulfate proteoglycan metabolic process activity versus PTPRU in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTPRU →	+0.965	+0.181	<.001	.002	3	5
GBM	COL6A2 →	+1.101	+0.143	.005	.003	3	4
COAD	PGAM4 →	+0.235	+0.133	<.001	.006	3	4
LSCC	CD63 →	+0.503	+0.192	<.001	<.001	3	4
BRCA	TGFB1I1 →	+0.732	+0.143	.002	.005	3	4
BRCA	KCNMB1 →	+0.616	+0.159	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050655 vs PTPRU — LSCC

Explore this scatter interactively →