Dermatan sulfate proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Dermatan sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAPC1, ARL4C, and RPS6KB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAPC1 grouped by Dermatan sulfate proteoglycan metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SNAPC1 →	-1.390	-1.050	<.001	<.001	3	5
BONE	ARL4C →	-2.974	-1.807	.001	<.001	3	5
CNS	RPS6KB1 →	+0.597	+1.049	.001	.001	3	5
KIDNEY	AKNA →	-0.996	-1.217	.006	<.001	3	4
OVARY	GSPT1 →	+0.686	+0.923	.001	.002	3	4
OVARY	EIF4G1 →	+0.569	+1.152	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAPC1 by Dermatan sulfate proteoglycan metabolic process activity — CNS

Explore this box plot interactively →