Chondroitin sulfate proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Chondroitin sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, BOLA3, and IL15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Chondroitin sulfate proteoglycan metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BCL2L1 →	-1.189	-0.985	.003	.002	3	4
OVARY	BOLA3 →	+0.751	+1.223	<.001	<.001	3	4
LIVER	IL15 →	-1.989	-0.583	.001	<.001	3	4
STOMACH	DTX2 →	-1.612	-1.242	.003	.001	3	4
URINARY_TRACT	TCP11L2 →	-1.406	-1.740	.009	<.001	2	5
BONE	RTN1 →	+2.894	+1.480	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Chondroitin sulfate proteoglycan metabolic process activity — STOMACH

Explore this box plot interactively →