Chondroitin sulfate proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Chondroitin sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, HEXB, and ARFGEF3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondroitin sulfate proteoglycan metabolic process activity versus UGDH in KIDNEY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	UGDH →	+1.877	+1.165	.003	<.001	3	10
BONE	HEXB →	+2.086	+1.332	.009	.005	3	6
BREAST	ARFGEF3 →	+1.985	+1.106	<.001	.001	3	6
LARGE_INTESTINE	MYB →	+1.941	+0.844	<.001	<.001	3	6
LUNG_NSCLC_LUAD	HNF4G →	+1.450	+1.092	<.001	<.001	3	6
LIVER	TMEM135 →	+1.482	+1.301	.004	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050654 vs UGDH — KIDNEY

Explore this scatter interactively →