Dermatan sulfate proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dermatan sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX1, FKBP14, and SEC22A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RUNX1 grouped by Dermatan sulfate proteoglycan biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RUNX1 →	-1.575	-0.883	.001	.007	3	4
PANCREAS	FKBP14 →	+0.676	+0.775	.004	.006	3	4
SOFT_TISSUE	SEC22A →	+0.764	+1.518	.002	.003	2	5
LUNG_SCLC	SEL1L3 →	-1.877	-1.213	.003	.001	3	4
BONE	RPS3 →	+0.742	+1.875	.008	<.001	3	4
STOMACH	ABHD2 →	-1.927	-1.178	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RUNX1 by Dermatan sulfate proteoglycan biosynthetic process activity — SKIN

Explore this box plot interactively →