Dermatan sulfate proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dermatan sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCALD, SEC23A, and ANLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dermatan sulfate proteoglycan biosynthetic process activity versus NCALD in CNS (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NCALD →	+1.198	+0.680	.007	.002	3	4
OVARY	SEC23A →	-0.956	-1.307	.004	.001	3	4
OVARY	ANLN →	-1.461	-1.409	.005	<.001	3	4
OVARY	MCM8 →	-0.853	-1.190	.002	.001	3	4
SKIN	IFI27L2 →	-1.213	-0.582	<.001	.004	3	3
URINARY_TRACT	ADGRL1 →	+2.644	+0.623	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050651 vs NCALD — CNS

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