Chondroitin sulfate proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Chondroitin sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB1P20, PPIAP67, and DDX18P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondroitin sulfate proteoglycan biosynthetic process activity versus HMGB1P20 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HMGB1P20 →	+0.389	+0.170	.006	<.001	3	4
HNSC	PPIAP67 →	-0.626	-0.570	<.001	<.001	3	4
OV	DDX18P3 →	+0.288	+0.154	.004	.001	3	4
OV	GAPDHP63 →	+1.478	+0.209	.004	<.001	3	4
OV	ANXA2P2 →	+1.336	+0.180	<.001	<.001	3	4
OV	GAPDHP65 →	+1.341	+0.163	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050650 vs HMGB1P20 — OV

Explore this scatter interactively →