Chondroitin sulfate proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Chondroitin sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCP11L2, NHS, and SLC22A18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCP11L2 grouped by Chondroitin sulfate proteoglycan biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TCP11L2 →	-1.086	-1.439	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	NHS →	-1.266	-1.224	<.001	.001	3	5
CNS	SLC22A18 →	-1.162	-1.022	.001	<.001	3	4
SKIN	AJUBA →	-1.268	-0.722	<.001	.008	2	5
SKIN	TAPBPL →	-0.702	-0.600	.003	.006	3	4
UPPER_AERODIGESTIVE_TRACT	LEMD2 →	-0.666	-1.207	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCP11L2 by Chondroitin sulfate proteoglycan biosynthetic process activity — LIVER

Explore this box plot interactively →