Chondroitin sulfate proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Chondroitin sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, DDC, and DDX51, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondroitin sulfate proteoglycan biosynthetic process activity versus UGDH in LUNG_NSCLC_LUAD (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UGDH →	+2.286	+1.324	<.001	<.001	3	16
STOMACH	DDC →	+4.187	+1.273	<.001	<.001	3	6
URINARY_TRACT	DDX51 →	+0.605	+1.396	.008	.002	3	5
LUNG_NSCLC_LUAD	GSR →	+1.910	+1.127	<.001	<.001	3	5
OVARY	KIF20A →	-0.876	-1.111	.002	<.001	3	5
LUNG_NSCLC_LUSC	SMIM14 →	+2.635	+2.063	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050650 vs UGDH — LUNG_NSCLC_LUAD

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