Catecholamine secretion

pathway activity — cross-omics
GO:0050432Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Catecholamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM5, MCM6, and CAD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAMCM5 →-0.470-0.033.001.00235
UCECMCM6 →-0.500-0.040<.001.00335
BRCACAD →-0.214-0.040<.001<.00135
COADCHGB_S311 →+1.466+0.038.003.00634
UCECMCM2 →-0.521-0.049.001.00434
UCECMCM3 →-0.428-0.040.001.00434
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration