3'-phosphoadenosine 5'-phosphosulfate metabolic process

Across TCGA patient cohorts, RNA activity of the 3'-phosphoadenosine 5'-phosphosulfate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAPSS2, BLNK, and LAS1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-phosphoadenosine 5'-phosphosulfate metabolic process activity versus PAPSS2 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PAPSS2 →	+0.437	+0.059	<.001	<.001	3	6
OV	BLNK →	+0.444	+0.043	.001	.005	3	5
BRCA	LAS1L →	-0.187	-0.041	.008	.002	3	5
GBM	ZFP36L1_S54 →	+0.509	+0.069	.001	<.001	3	4
HNSC	GDI2 →	+0.220	+0.070	.001	.003	3	4
COAD	SIN3B →	-0.210	-0.032	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050427 vs PAPSS2 — OV

Explore this scatter interactively →