3'-phosphoadenosine 5'-phosphosulfate metabolic process

Across TCGA patient cohorts, RNA activity of the 3'-phosphoadenosine 5'-phosphosulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, SPARC, and FN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-phosphoadenosine 5'-phosphosulfate metabolic process activity versus ITGAV in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGAV →	+0.906	+0.178	.003	.002	3	6
OV	SPARC →	+1.406	+0.210	.002	.002	3	5
OV	FN1 →	+1.718	+0.168	.001	.002	3	5
OV	CCN2 →	+1.414	+0.210	.002	<.001	3	5
OV	COL8A1 →	+1.825	+0.251	.001	<.001	3	5
OV	SETD7 →	+0.849	+0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050427 vs ITGAV — OV

Explore this scatter interactively →