3'-phosphoadenosine 5'-phosphosulfate metabolic process

Across TCGA patient cohorts, RNA activity of the 3'-phosphoadenosine 5'-phosphosulfate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB5, PAPSS2, and SPEN_S1261, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-phosphoadenosine 5'-phosphosulfate metabolic process activity versus ITGB5 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGB5 →	+0.589	+0.238	.001	<.001	3	5
UCEC	PAPSS2 →	+0.792	+0.259	<.001	<.001	3	5
LSCC	SPEN_S1261 →	-1.041	-0.197	.001	.002	2	5
GBM	TERF2 →	-0.308	-0.166	<.001	<.001	3	4
BRCA	VCAN_S1349 →	+1.197	+0.255	<.001	<.001	3	4
OV	SCAF4 →	-0.362	-0.261	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050427 vs ITGB5 — GBM

Explore this scatter interactively →