3'-phosphoadenosine 5'-phosphosulfate metabolic process

Across TCGA cell cohorts, RNA activity of the 3'-phosphoadenosine 5'-phosphosulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXN, MRPS11, and MTCL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FXN grouped by 3'-phosphoadenosine 5'-phosphosulfate metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXN →	+0.998	+1.345	.003	.002	3	5
LUNG_NSCLC_LUSC	MRPS11 →	+0.573	+1.219	.004	.006	3	4
BLOOD_Leukemia	MTCL1 →	+1.829	+1.066	.003	.006	3	4
OESOPHAGUS	MPZL3 →	-0.760	-1.545	.007	<.001	2	4
OESOPHAGUS	TYMS →	+1.641	+1.294	.002	.001	3	3
OESOPHAGUS	DDAH2 →	-1.045	-1.082	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FXN by 3'-phosphoadenosine 5'-phosphosulfate metabolic process activity — OESOPHAGUS

Explore this box plot interactively →