3'-phosphoadenosine 5'-phosphosulfate metabolic process

Across TCGA cell cohorts, RNA activity of the 3'-phosphoadenosine 5'-phosphosulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN2, MYL5, and CGAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-phosphoadenosine 5'-phosphosulfate metabolic process activity versus SFXN2 in LUNG_NSCLC_LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SFXN2 →	+0.797	+0.642	.002	.003	3	5
BONE	MYL5 →	+2.342	+1.869	<.001	<.001	3	5
BLOOD_Leukemia	CGAS →	-1.458	-0.361	<.001	.006	3	4
SOFT_TISSUE	CHMP4B →	-1.012	-1.878	.007	.003	3	4
OVARY	AGRN →	-1.150	-1.144	.008	.009	2	5
CNS	RPL41 →	+0.632	+1.419	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050427 vs SFXN2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →