Chromosome localization

Across TCGA patient cohorts, RNA activity of the Chromosome localization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PADI1, TAF10, and STK40, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome localization activity versus PADI1 in COAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PADI1 →	-0.661	-0.153	<.001	.002	3	2
COAD	TAF10 →	+0.244	+0.173	.007	<.001	3	2
COAD	STK40 →	+0.349	+0.186	.003	.001	3	2
COAD	RPL36AP43 →	+0.465	+0.175	.008	.002	3	2
COAD	KRT18P7 →	+0.197	+0.184	.009	.007	3	2
OV	CLEC11A →	-1.859	-0.234	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050000 vs PADI1 — COAD

Explore this scatter interactively →