Host-mediated regulation of intestinal microbiota composition

Across TCGA patient cohorts, RNA activity of the Host-mediated regulation of intestinal microbiota composition pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MDC1, IFNGR1, and TTC39B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Host-mediated regulation of intestinal microbiota composition activity versus MDC1 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MDC1 →	-0.368	-0.063	.001	<.001	3	7
BRCA	IFNGR1 →	+0.404	+0.045	.001	.008	3	6
LUAD	TTC39B →	+0.352	+0.050	<.001	<.001	3	6
LUAD	STMN1 →	-0.387	-0.060	.001	<.001	3	6
LUAD	FCGBP →	+1.091	+0.070	<.001	<.001	3	5
PDAC	SPI1 →	+0.656	+0.073	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048874 vs MDC1 — LSCC

Explore this scatter interactively →