Host-mediated regulation of intestinal microbiota composition

Across TCGA patient cohorts, RNA activity of the Host-mediated regulation of intestinal microbiota composition pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP13A4, SELL, and CCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Host-mediated regulation of intestinal microbiota composition activity versus ATP13A4 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATP13A4 →	+1.694	+0.775	<.001	<.001	3	5
BRCA	SELL →	+0.832	+0.536	<.001	<.001	3	5
BRCA	CCR2 →	+0.928	+0.737	<.001	<.001	3	4
GBM	CD53 →	+0.666	+0.428	.001	.005	3	4
BRCA	EIF4A1 →	-0.304	-0.666	.008	<.001	3	4
BRCA	LAPTM5 →	+0.500	+0.510	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048874 vs ATP13A4 — HNSC

Explore this scatter interactively →