Host-mediated regulation of intestinal microbiota composition

Across TCGA cell cohorts, RNA activity of the Host-mediated regulation of intestinal microbiota composition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRAC1, ARHGAP21, and RAI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRAC1 grouped by Host-mediated regulation of intestinal microbiota composition-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHRAC1 →	-0.569	-0.920	.001	.009	3	4
BLOOD_Leukemia	ARHGAP21 →	-1.650	-1.027	.004	.003	3	4
BLOOD_Leukemia	RAI1 →	-1.294	-1.491	<.001	<.001	3	4
BLOOD_Leukemia	FYTTD1 →	-1.184	-1.231	.005	.005	3	4
BLOOD_Leukemia	ASXL1 →	-0.831	-1.446	.009	.004	3	4
BLOOD_Leukemia	ISG20 →	-1.347	-1.109	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRAC1 by Host-mediated regulation of intestinal microbiota composition activity — BLOOD_Leukemia

Explore this box plot interactively →