Host-mediated regulation of intestinal microbiota composition

Across TCGA cell cohorts, RNA activity of the Host-mediated regulation of intestinal microbiota composition pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIPR, SAE1, and BIRC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GIPR grouped by Host-mediated regulation of intestinal microbiota composition-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GIPR →	-0.179	-1.255	.002	<.001	3	5
LUNG_NSCLC_LUAD	SAE1 →	+0.119	+0.856	.007	.005	3	4
LUNG_NSCLC_LUSC	BIRC5 →	+0.317	+1.274	<.001	<.001	3	4
SOFT_TISSUE	MORF4L1 →	-0.274	-1.430	.001	.005	3	4
LUNG_NSCLC_LUSC	UGT2A1 →	+0.307	+1.478	.001	.004	3	4
STOMACH	PLCXD1 →	+0.285	+1.540	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GIPR by Host-mediated regulation of intestinal microbiota composition activity — BLOOD_Leukemia

Explore this box plot interactively →