Homeostasis of number of cells within a tissue

Across TCGA patient cohorts, RNA activity of the Homeostasis of number of cells within a tissue pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNB4, EVI2B_S268, and SASH3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homeostasis of number of cells within a tissue activity versus GNB4 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GNB4 →	+0.462	+0.067	<.001	<.001	3	9
LSCC	EVI2B_S268 →	+0.896	+0.049	<.001	<.001	3	8
BRCA	SASH3 →	+0.478	+0.041	<.001	<.001	3	8
UCEC	WIPF1 →	+0.434	+0.057	<.001	.004	3	8
UCEC	KCTD12 →	+0.457	+0.059	.001	<.001	3	8
UCEC	ANKRD44 →	+0.448	+0.052	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048873 vs GNB4 — LSCC

Explore this scatter interactively →