Homeostasis of number of cells within a tissue

Across TCGA patient cohorts, RNA activity of the Homeostasis of number of cells within a tissue pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPSAP50, TSPYL2, and PIGL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homeostasis of number of cells within a tissue activity versus RPSAP50 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPSAP50 →	+0.265	+0.427	.005	.005	3	5
OV	TSPYL2 →	+0.649	+0.669	.006	.004	3	4
OV	PIGL →	+0.457	+0.724	.002	<.001	3	3
HNSC	GBGT1 →	+0.560	+1.092	<.001	<.001	3	3
HNSC	VENTX →	+0.412	+0.652	<.001	.003	2	4
HNSC	GNG7 →	+0.428	+0.548	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048873 vs RPSAP50 — CCRCC

Explore this scatter interactively →