Homeostasis of number of cells within a tissue

Across TCGA cell cohorts, RNA activity of the Homeostasis of number of cells within a tissue pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKFB2, TPRN, and PLEKHA7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFKFB2 grouped by Homeostasis of number of cells within a tissue-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PFKFB2 →	+2.351	+1.133	.005	.007	3	6
STOMACH	TPRN →	+1.118	+0.411	.002	.001	3	5
LIVER	PLEKHA7 →	+1.900	+1.263	.008	.004	3	4
LARGE_INTESTINE	LAD1 →	+2.338	+0.830	.006	.002	3	4
LARGE_INTESTINE	TMTC2 →	+0.842	+0.651	.003	.003	3	4
LARGE_INTESTINE	REPIN1 →	+0.583	+0.709	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFKFB2 by Homeostasis of number of cells within a tissue activity — LUNG_SCLC

Explore this box plot interactively →