Homeostasis of number of cells within a tissue

Across TCGA cell cohorts, RNA activity of the Homeostasis of number of cells within a tissue pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD26, APEH, and GPD1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homeostasis of number of cells within a tissue activity versus ANKRD26 in LARGE_INTESTINE (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD26 →	-1.175	-0.147	.004	.009	3	3
LARGE_INTESTINE	APEH →	+0.721	+0.138	.009	.001	2	4
BREAST	GPD1L →	+1.622	+0.216	.001	.005	3	3
BREAST	ATF7IP →	-0.853	-0.270	.004	.002	3	3
BREAST	SVBP →	-1.205	-0.236	.003	.001	3	3
BLOOD_Leukemia	SLC7A8 →	+2.055	+0.209	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048873 vs ANKRD26 — LARGE_INTESTINE

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