Stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEL1L2, DKKL1, and SCN1B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell differentiation activity versus SEL1L2 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEL1L2 →	-0.069	-0.209	.005	.002	3	1
COAD	DKKL1 →	+0.241	+0.262	<.001	.007	3	1
COAD	SCN1B →	-0.546	-0.189	.003	.004	3	1
COAD	SSPN →	-1.040	-0.266	.001	.004	3	1
COAD	OMD →	-1.843	-0.271	.001	.001	3	1
COAD	KDM5D →	-2.437	-0.191	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048863 vs SEL1L2 — COAD

Explore this scatter interactively →