Stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA3, GSTM2, and COX17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA3 grouped by Stem cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PHLDA3 →	-2.340	-0.148	.005	.004	3	4
SOFT_TISSUE	GSTM2 →	-3.127	-0.176	<.001	.007	3	4
LUNG_SCLC	COX17 →	-1.530	-0.261	.001	.004	3	4
STOMACH	CCNH →	+1.126	+0.222	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	DOCK7 →	+1.692	+0.152	.001	<.001	3	4
OVARY	MTRF1L →	+0.580	+0.129	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA3 by Stem cell differentiation activity — OVARY

Explore this box plot interactively →