Stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP2, MSMO1, and PASK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell differentiation activity versus TIMP2 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TIMP2 →	+2.337	+0.239	.002	.007	3	5
KIDNEY	MSMO1 →	+1.989	+0.234	<.001	.003	3	4
URINARY_TRACT	PASK →	-1.011	-0.291	.003	.005	3	4
BONE	PLBD2 →	+1.110	+0.248	.003	.002	3	4
LARGE_INTESTINE	TNFRSF12A →	+1.601	+0.193	.003	.008	2	5
SKIN	VDAC3 →	-0.777	-0.267	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048863 vs TIMP2 — BONE

Explore this scatter interactively →