Neural nucleus development

Across TCGA patient cohorts, RNA activity of the Neural nucleus development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NDRG2, CAMK1D, and EFHD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural nucleus development activity versus NDRG2 in GBM (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NDRG2 →	+0.487	+0.067	<.001	<.001	3	6
GBM	CAMK1D →	+0.567	+0.063	<.001	<.001	3	5
UCEC	EFHD1 →	+0.429	+0.040	.001	.004	3	5
GBM	ACIN1_S729 →	-0.333	-0.043	.001	.002	3	5
BRCA	ASAP3 →	+0.356	+0.041	<.001	<.001	3	5
PDAC	PEAK1_S826 →	+0.400	+0.026	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048857 vs NDRG2 — GBM

Explore this scatter interactively →