Neural nucleus development

Across TCGA patient cohorts, RNA activity of the Neural nucleus development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM171A1, ADH1C, and BSPRY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural nucleus development activity versus FAM171A1 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAM171A1 →	+1.370	+0.202	<.001	.003	3	5
OV	ADH1C →	+0.966	+0.169	<.001	<.001	3	5
PDAC	BSPRY →	+0.638	+0.109	<.001	.002	3	4
GBM	ABHD17B →	+0.623	+0.199	.006	.004	3	4
GBM	ATP8A1 →	+2.475	+0.311	.002	.008	3	4
GBM	REPS2 →	+1.167	+0.205	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048857 vs FAM171A1 — GBM

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