Neural nucleus development

Across TCGA patient cohorts, RNA activity of the Neural nucleus development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AUH, SEPTIN4_S117, and VPS13D_S1709, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural nucleus development activity versus AUH in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AUH →	+0.965	+0.220	<.001	.001	3	4
GBM	SEPTIN4_S117 →	+1.538	+0.232	<.001	<.001	3	3
OV	VPS13D_S1709 →	-0.468	-0.157	<.001	<.001	3	3
OV	ZNF592_S691 →	-0.735	-0.232	<.001	<.001	3	3
OV	CKAP5_T832 →	-0.662	-0.168	<.001	<.001	3	3
UCEC	ECM2 →	-0.700	-0.193	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048857 vs AUH — GBM

Explore this scatter interactively →