Neural nucleus development

Across TCGA cell cohorts, RNA activity of the Neural nucleus development pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YWHAH, YWHAG, and GPI, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural nucleus development activity versus YWHAH in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	YWHAH →	+2.263	+0.273	.004	.009	3	13
URINARY_TRACT	YWHAG →	+2.059	+0.300	.004	.002	3	13
URINARY_TRACT	GPI →	+2.665	+0.277	.003	.005	3	12
URINARY_TRACT	TPI1 →	+3.338	+0.335	.005	.001	3	12
URINARY_TRACT	G6PD →	+1.939	+0.292	.001	<.001	3	12
BREAST	OTUB1 →	+1.445	+0.239	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048857 vs YWHAH — URINARY_TRACT

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