Forebrain morphogenesis

Across TCGA patient cohorts, RNA activity of the Forebrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NF1, MIB1, and MED13, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain morphogenesis activity versus NF1 in HNSC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NF1 →	+0.801	+0.068	<.001	<.001	3	29
THYM	MIB1 →	+0.947	+0.045	<.001	<.001	3	28
UVM	MED13 →	+0.979	+0.049	<.001	<.001	3	27
UVM	TAOK1 →	+1.130	+0.049	<.001	<.001	3	27
UVM	ARID4B →	+1.110	+0.052	<.001	<.001	3	27
UVM	RAB3GAP2 →	+0.858	+0.047	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048853 vs NF1 — HNSC

Explore this scatter interactively →