Forebrain morphogenesis

Across TCGA patient cohorts, RNA activity of the Forebrain morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMSAP2, WNT5A, and FARP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain morphogenesis activity versus CAMSAP2 in PDAC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CAMSAP2 →	+0.291	+0.065	<.001	<.001	3	7
OV	WNT5A →	+1.072	+0.089	.001	<.001	3	6
COAD	FARP1 →	+0.321	+0.051	<.001	<.001	3	6
COAD	PSME2 →	-0.346	-0.045	<.001	<.001	3	6
CCRCC	RILPL1 →	+0.284	+0.061	.005	.006	3	5
PDAC	TAOK1 →	+0.116	+0.048	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048853 vs CAMSAP2 — PDAC

Explore this scatter interactively →