Forebrain morphogenesis

Across TCGA patient cohorts, RNA activity of the Forebrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR25, CNR2, and CD79B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain morphogenesis activity versus GPR25 in LUAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GPR25 →	-0.246	-0.308	.007	.002	3	4
LUAD	CNR2 →	-0.341	-0.420	.005	.003	3	4
HNSC	CD79B →	-0.775	-0.354	.002	.006	2	5
GBM	GIMAP1 →	-0.418	-0.178	.007	.002	3	4
HNSC	SLAMF1 →	-0.630	-0.380	.002	.001	3	4
GBM	NF1 →	+0.431	+0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048853 vs GPR25 — LUAD

Explore this scatter interactively →