Forebrain morphogenesis

Across TCGA cell cohorts, RNA activity of the Forebrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRN, MIGA2, and RPS24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRN grouped by Forebrain morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GRN →	-1.391	-1.705	<.001	<.001	3	6
OESOPHAGUS	MIGA2 →	-0.722	-1.145	.005	.008	3	5
BLOOD_Leukemia	RPS24 →	-0.758	-1.483	.003	<.001	3	4
SOFT_TISSUE	GALK1 →	-0.951	-1.081	.001	.004	3	4
SOFT_TISSUE	NEBL →	+2.877	+1.446	.005	<.001	3	4
LUNG_SCLC	PLAG1 →	+1.191	+1.214	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRN by Forebrain morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →